Using the INSPIRAL program to search for gravitational waves from low-mass binary inspiral

The INSPIRAL program is the LIGO Scientific Collaboration's computational engine for the search for gravitational waves from binary neutron stars and sub-solar mass black holes. We describe how this program, which makes use of the FINDCHIRP algorithm (discussed in a companion paper), is integrated into a sophisticated data analysis pipeline that was used in the search for low-mass binary inspirals in data taken during the second LIGO science run.Comment: 11 pages, 3 figures, submitted to Classical and Quantum Gravity for the special issue of the GWDAW9 Proceeding

Noise and Disturbance of Qubit Measurements: An Information-Theoretic Characterisation

Information-theoretic definitions for the noise associated with a quantum measurement and the corresponding disturbance to the state of the system have recently been introduced [F. Buscemi et al., Phys. Rev. Lett. 112, 050401 (2014)]. These definitions are invariant under relabelling of measurement outcomes, and lend themselves readily to the formulation of state-independent uncertainty relations both for the joint estimate of observables (noise-noise relations) and the noise-disturbance tradeoff. Here we derive such relations for incompatible qubit observables, which we prove to be tight in the case of joint estimates, and present progress towards fully characterising the noise-disturbance tradeoff. In doing so, we show that the set of obtainable noise-noise values for such observables is convex, whereas the conjectured form for the set of obtainable noise-disturbance values is not. Furthermore, projective measurements are not optimal with respect to the joint-measurement noise or noise-disturbance tradeoffs. Interestingly, it seems that four-outcome measurements are needed in the former case, whereas three-outcome measurements are optimal in the latter.Comment: Minor changes, corresponds to final published version. 14 pages, 5 figure

Von Neumann Normalisation of a Quantum Random Number Generator

In this paper we study von Neumann un-biasing normalisation for ideal and real quantum random number generators, operating on finite strings or infinite bit sequences. In the ideal cases one can obtain the desired un-biasing. This relies critically on the independence of the source, a notion we rigorously define for our model. In real cases, affected by imperfections in measurement and hardware, one cannot achieve a true un-biasing, but, if the bias "drifts sufficiently slowly", the result can be arbitrarily close to un-biasing. For infinite sequences, normalisation can both increase or decrease the (algorithmic) randomness of the generated sequences. A successful application of von Neumann normalisation---in fact, any un-biasing transformation---does exactly what it promises, un-biasing, one (among infinitely many) symptoms of randomness; it will not produce "true" randomness.Comment: 27 pages, 2 figures. Updated to published versio

The Cost of US Pharmaceutical Price Reductions: A Financial Simulation Model of R&D Decisions

Previous empirical studies that have examined the links between pharmaceutical price controls, profits, cash flows, and investment in research and development (R&D) have been largely based on retrospective statistical analyses of firm- and/or industry-level data. These studies, which have contributed numerous insights and findings to the literature, relied upon ad hoc reduced-form model specifications. In the current paper we take a very different approach: a prospective micro-simulation approach. Using Monte Carlo techniques we model how future price controls in the U.S. will impact early-stage product development decisions in the pharmaceutical industry. This is done within the context of a net present value (NPV) framework that appropriately reflects the uncertainty associated with R&D project technical success, development costs, and future revenues. Using partial-information estimators calibrated with the most contemporary clinical and economic data available, we demonstrate how pharmaceutical price controls will significantly diminish the incentives to undertake early-stage R&D investment. For example, we estimate that cutting prices by 40 to 50 percent in the U.S. will lead to between 30 to 60 percent fewer R&D projects being undertaken (in early-stage development). Given the recent legislative efforts to control prescription drug prices in the U.S., and the likelihood that price controls will prevail as a result, it is important to better understand the firm response to such a regulatory change.

Gaze-based teleprosthetic enables intuitive continuous control of complex robot arm use: Writing & drawing

Eye tracking is a powerful mean for assistive technologies for people with movement disorders, paralysis and amputees. We present a highly intuitive eye tracking-controlled robot arm operating in 3-dimensional space based on the user's gaze target point that enables tele-writing and drawing. The usability and intuitive usage was assessed by a “tele” writing experiment with 8 subjects that learned to operate the system within minutes of first time use. These subjects were naive to the system and the task and had to write three letters on a white board with a white board pen attached to the robot arm's endpoint. The instructions are to imagine they were writing text with the pen and look where the pen would be going, they had to write the letters as fast and as accurate as possible, given a letter size template. Subjects were able to perform the task with facility and accuracy, and movements of the arm did not interfere with subjects ability to control their visual attention so as to enable smooth writing. On the basis of five consecutive trials there was a significant decrease in the total time used and the total number of commands sent to move the robot arm from the first to the second trial but no further improvement thereafter, suggesting that within writing 6 letters subjects had mastered the ability to control the system. Our work demonstrates that eye tracking is a powerful means to control robot arms in closed-loop and real-time, outperforming other invasive and non-invasive approaches to Brain-Machine-Interfaces in terms of calibration time (<;2 minutes), training time (<;10 minutes), interface technology costs. We suggests that gaze-based decoding of action intention may well become one of the most efficient ways to interface with robotic actuators - i.e. Brain-Robot-Interfaces - and become useful beyond paralysed and amputee users also for the general teleoperation of robotic and exoskeleton in human augmentation

The Background Field Method as a Canonical Transformation

We construct explicitly the canonical transformation that controls the full dependence (local and non-local) of the vertex functional of a Yang-Mills theory on a background field. After showing that the canonical transformation found is nothing but a direct field-theoretic generalization of the Lie transform of classical analytical mechanics, we comment on a number of possible applications, and in particular the non perturbative implementation of the background field method on the lattice, the background field formulation of the two particle irreducible formalism, and, finally, the formulation of the Schwinger-Dyson series in the presence of topologically non-trivial configurations.Comment: 11 pages, REVTeX. References added, some explanations extended. Final version to appear in the journa

On the definition and characterisation of multipartite causal (non)separability

The concept of causal nonseparability has been recently introduced, in opposition to that of causal separability, to qualify physical processes that locally abide by the laws of quantum theory, but cannot be embedded in a well-defined global causal structure. While the definition is unambiguous in the bipartite case, its generalisation to the multipartite case is not so straightforward. Two seemingly different generalisations have been proposed, one for a restricted tripartite scenario and one for the general multipartite case. Here we compare the two, showing that they are in fact inequivalent. We propose our own definition of causal (non)separability for the general case, which---although a priori subtly different---turns out to be equivalent to the concept of "extensible causal (non)separability" introduced before, and which we argue is a more natural definition for general multipartite scenarios. We then derive necessary, as well as sufficient conditions to characterise causally (non)separable processes in practice. These allow one to devise practical tests, by generalising the tool of witnesses of causal nonseparability

Parrondo's games with chaotic switching

This paper investigates the different effects of chaotic switching on Parrondo's games, as compared to random and periodic switching. The rate of winning of Parrondo's games with chaotic switching depends on coefficient(s) defining the chaotic generator, initial conditions of the chaotic sequence and the proportion of Game A played. Maximum rate of winning can be obtained with all the above mentioned factors properly set, and this occurs when chaotic switching approaches periodic behavior.Comment: 11 pages, 9 figure